期刊
SCIENCE
卷 324, 期 5930, 页码 1080-1084出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1168878
关键词
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资金
- Stanford Graduate Fellowship
- NIH National Research Service award
- Fonds National de la Recherche Scientifique
- NARSAD
- Fondation Leon Fredericq
- National Institute on Drug Abuse (NIDA)
- Defense Advanced Research Projects Agency
- NSF
- National Institute of Mental Health
- McKnight, Coulter, Snyder, Albert Yu and Mary Bechmann, and Keck foundations
Natural rewards and drugs of abuse can alter dopamine signaling, and ventral tegmental area (VTA) dopaminergic neurons are known to fire action potentials tonically or phasically under different behavioral conditions. However, without technology to control specific neurons with appropriate temporal precision in freely behaving mammals, the causal role of these action potential patterns in driving behavioral changes has been unclear. We used optogenetic tools to selectively stimulate VTA dopaminergic neuron action potential firing in freely behaving mammals. We found that phasic activation of these neurons was sufficient to drive behavioral conditioning and elicited dopamine transients with magnitudes not achieved by longer, lower-frequency spiking. These results demonstrate that phasic dopaminergic activity is sufficient to mediate mammalian behavioral conditioning.
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