期刊
SCIENCE
卷 327, 期 5961, 页码 46-50出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1174621
关键词
-
资金
- European Union [LSHB-CT2007-037740]
- Deutsche Forschungsgemeinschaft [1175]
- Bundesministerium fur Bildung und Forschung BioChance Plus [0313827]
Cell membranes display a tremendous complexity of lipids and proteins designed to perform the functions cells require. To coordinate these functions, the membrane is able to laterally segregate its constituents. This capability is based on dynamic liquid-liquid immiscibility and underlies the raft concept of membrane subcompartmentalization. Lipid rafts are fluctuating nanoscale assemblies of sphingolipid, cholesterol, and proteins that can be stabilized to coalesce, forming platforms that function in membrane signaling and trafficking. Here we review the evidence for how this principle combines the potential for sphingolipid-cholesterol self-assembly with protein specificity to selectively focus membrane bioactivity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据