期刊
SCIENCE
卷 325, 期 5938, 页码 328-332出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1173155
关键词
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资金
- Swiss National Foundation
- Clayton Medical Research Foundation Inc.
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) [PO1 DK026741-29]
- Direct For Biological Sciences [0958111] Funding Source: National Science Foundation
- Div Of Molecular and Cellular Bioscience [0958111] Funding Source: National Science Foundation
Amyloids are highly organized cross-beta-sheet-rich protein or peptide aggregates that are associated with pathological conditions including Alzheimer's disease and type II diabetes. However, amyloids may also have a normal biological function, as demonstrated by fungal prions, which are involved in prion replication, and the amyloid protein Pmel17, which is involved in mammalian skin pigmentation. We found that peptide and protein hormones in secretory granules of the endocrine system are stored in an amyloid-like cross-beta-sheet-rich conformation. Thus, functional amyloids in the pituitary and other organs can contribute to normal cell and tissue physiology.
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