期刊
SCIENCE
卷 326, 期 5954, 页码 865-867出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1178158
关键词
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资金
- National Human Genome Research Institute
- Dorothy Russell Havemeyer Foundation
- Volkswagen Foundation
- Morris Animal Foundation
- Centro di Eccellenza di Genomica in Campo Biomedico e Agrario
- Programmi di Ricerca Scientifica di Rilevante Interesse Nazionale [PRIN-2006]
- European Science Foundation
- Direct For Biological Sciences [850237] Funding Source: National Science Foundation
- Emerging Frontiers [850237] Funding Source: National Science Foundation
We report a high-quality draft sequence of the genome of the horse ( Equus caballus). The genome is relatively repetitive but has little segmental duplication. Chromosomes appear to have undergone few historical rearrangements: 53% of equine chromosomes show conserved synteny to a single human chromosome. Equine chromosome 11 is shown to have an evolutionary new centromere devoid of centromeric satellite DNA, suggesting that centromeric function may arise before satellite repeat accumulation. Linkage disequilibrium, showing the influences of early domestication of large herds of female horses, is intermediate in length between dog and human, and there is long-range haplotype sharing among breeds.
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