期刊
SCIENCE
卷 323, 期 5917, 页码 1053-1057出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1166386
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资金
- Korea Science and Engineering Foundation National Core Research Center [R15-2004-033-05002-0)]
- Crop Functional Genomics Frontier Research Program [CG3132]
- National Research Foundation of Korea [2005-0049269, R15-2004-033-05002-0] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Aging induces gradual yet massive cell death in higher organisms, including annual plants. Even so, the underlying regulatory mechanisms are barely known, despite the long- standing interest in this topic. Here, we demonstrate that ORE1, which is a NAC ( NAM, ATAF, and CUC) transcription factor, positively regulates aging- induced cell death in Arabidopsis leaves. ORE1 expression is up- regulated concurrently with leaf aging by EIN2 but is negatively regulated by miR164. miR164 expression gradually decreases with aging through negative regulation by EIN2, which leads to the elaborate up- regulation of ORE1 expression. However, EIN2 still contributes to aging- induced cell death in the absence of ORE1. The trifurcate feed- forward pathway involving ORE1, miR164, and EIN2 provides a highly robust regulation to ensure that aging induces cell death in Arabidopsis leaves.
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