期刊
SCIENCE
卷 325, 期 5937, 页码 210-213出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1173215
关键词
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资金
- Lookout
- Mathers Foundations
- Kavli Institute for Brain and Mind
- NIH [NS-050217]
- Huntingtons and Parkinsons Disease Research Clinics at the Brain Repair Centre, University of Cambridge
- MaxNetAging
- NCCR Neural Plasticity and Repair
- Marshalls and Jack Kent Cooke Foundation
- Medical Research Council [G0300723B, G0001354, G0001354B] Funding Source: researchfish
The dentate gyrus (DG) of the mammalian hippocampus is hypothesized to mediate pattern separation-the formation of distinct and orthogonal representations of mnemonic information-and also undergoes neurogenesis throughout life. How neurogenesis contributes to hippocampal function is largely unknown. Using adult mice in which hippocampal neurogenesis was ablated, we found specific impairments in spatial discrimination with two behavioral assays: (i) a spatial navigation radial arm maze task and (ii) a spatial, but non-navigable, task in the mouse touch screen. Mice with ablated neurogenesis were impaired when stimuli were presented with little spatial separation, but not when stimuli were more widely separated in space. Thus, newborn neurons may be necessary for normal pattern separation function in the DG of adult mice.
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