期刊
SCIENCE
卷 326, 期 5952, 页码 585-589出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1179052
关键词
-
资金
- Whittemore Peterson Institute
- Whittemore Family foundation
- National Cancer Institute (NCI)
- NIH [HHSN26120080001E]
- NCI/ NIH [CA104943]
- U. S. DoD Prostate Cancer Research Program [W81XWH-07-1338]
- V Foundation for Cancer Research
- Charlotte Geyer Foundation
- Mal and Lea Bank
Chronic fatigue syndrome (CFS) is a debilitating disease of unknown etiology that is estimated to affect 17 million people worldwide. Studying peripheral blood mononuclear cells (PBMCs) from CFS patients, we identified DNA from a human gammaretrovirus, xenotropic murine leukemia virus-related virus (XMRV), in 68 of 101 patients (67%) as compared to 8 of 218 (3.7%) healthy controls. Cell culture experiments revealed that patient-derived XMRV is infectious and that both cell-associated and cell-free transmission of the virus are possible. Secondary viral infections were established in uninfected primary lymphocytes and indicator cell lines after their exposure to activated PBMCs, B cells, T cells, or plasma derived from CFS patients. These findings raise the possibility that XMRV may be a contributing factor in the pathogenesis of CFS.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据