期刊
SCIENCE
卷 326, 期 5958, 页码 1419-1424出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1175509
关键词
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资金
- INSERM
- Ville de Marseille and Region Provence Alpes Cote d'Azur
- Fondation pour la Recherche Medicale
- Agence Nationale pour la Recherche
- Fondation pour la Recherche sur le Cerveau
- Fondation Bettencourt Schueller
- CNRS
- European Fellowships
Brain function operates through the coordinated activation of neuronal assemblies. Graph theory predicts that scale-free topologies, which include hubs (superconnected nodes), are an effective design to orchestrate synchronization. Whether hubs are present in neuronal assemblies and coordinate network activity remains unknown. Using network dynamics imaging, online reconstruction of functional connectivity, and targeted whole-cell recordings in rats and mice, we found that developing hippocampal networks follow a scale-free topology, and we demonstrated the existence of functional hubs. Perturbation of a single hub influenced the entire network dynamics. Morphophysiological analysis revealed that hub cells are a subpopulation of gamma-aminobutyric acid-releasing (GABAergic) interneurons possessing widespread axonal arborizations. These findings establish a central role for GABAergic interneurons in shaping developing networks and help provide a conceptual framework for studying neuronal synchrony.
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