期刊
SCIENCE
卷 325, 期 5936, 页码 90-93出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1175865
关键词
-
资金
- Glasstone Fellowship
- Deutsche Forschungsgemeinschaft [BO1748-3, LE2130/2-1]
- UK Biotechnology and Biological Sciences Research Council
- European Union
- Wellcome Trust
- Biotechnology and Biological Sciences Research Council [BB/D011523/1] Funding Source: researchfish
- Medical Research Council [G9826944] Funding Source: researchfish
- BBSRC [BB/D011523/1] Funding Source: UKRI
- MRC [G9826944] Funding Source: UKRI
The finding that the metazoan hypoxic response is regulated by oxygen-dependent posttranslational hydroxylations, which regulate the activity and lifetime of hypoxia-inducible factor (HIF), has raised the question of whether other hydroxylases are involved in the regulation of gene expression. We reveal that the splicing factor U2 small nuclear ribonucleoprotein auxiliary factor 65-kilodalton subunit (U2AF65) undergoes posttranslational lysyl-5-hydroxylation catalyzed by the Fe(II) and 2-oxoglutarate-dependent dioxygenase Jumonji domain-6 protein (Jmjd6). Jmjd6 is a nuclear protein that has an important role in vertebrate development and is a human homolog of the HIF asparaginyl-hydroxylase. Jmjd6 is shown to change alternative RNA splicing of some, but not all, of the endogenous and reporter genes, supporting a specific role for Jmjd6 in the regulation of RNA splicing.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据