期刊
SCIENCE
卷 325, 期 5945, 页码 1250-1254出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1174921
关键词
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资金
- Jane Coffin Childs Memorial Fund for Medical Research fellowship
- NIH National Technology Center for Networks and NIH Pathway [U54 RR020843]
- Howard Hughes Medical Institute
Actin filaments are key components of the eukaryotic cytoskeleton that provide mechanical structure and generate forces during cell shape changes, growth, and migration. Actin filaments are dynamically assembled into higher-order structures at specified locations to regulate diverse functions. The Rab family of small guanosine triphosphatases is evolutionarily conserved and mediates intracellular vesicle trafficking. We found that Rab35 regulates the assembly of actin filaments during bristle development in Drosophila and filopodia formation in cultured cells. These effects were mediated by the actin-bundling protein fascin, which directly associated with active Rab35. Targeting Rab35 to the outer mitochondrial membrane triggered actin recruitment, demonstrating a role for an intracellular trafficking protein in localized actin assembly.
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