期刊
SCIENCE
卷 325, 期 5946, 页码 1394-1398出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1172645
关键词
-
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Research Fellowships of the Japan Society
- Grants-in-Aid for Scientific Research [21227008] Funding Source: KAKEN
Stem cells give rise to differentiated cell types but also preserve their undifferentiated state through cell self-renewal. With the use of transgenic mice, we found that the RNA-binding protein NANOS2 is essential for maintaining spermatogonial stem cells. Lineage-tracing analyses revealed that undifferentiated spermatogonia expressing Nanos2 self-renew and generate the entire spermatogenic cell lineage. Conditional disruption of postnatal Nanos2 depleted spermatogonial stem cell reserves, whereas mouse testes in which Nanos2 had been overexpressed accumulated spermatogonia with undifferentiated, stem cell-like properties. Thus, NANOS2 is a key stem cell regulator that is expressed in self-renewing spermatogonial stem cells and maintains the stem cell state during murine spermatogenesis.
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