期刊
SCIENCE
卷 323, 期 5914, 页码 614-617出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1166253
关键词
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资金
- UK Engineering and Physical Sciences Research Council [GR/T11036/01]
- NSF [CHE-0809058]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [0809058] Funding Source: National Science Foundation
- Engineering and Physical Sciences Research Council [GR/T11036/01] Funding Source: researchfish
Populations of certain unicellular organisms, such as suspensions of yeast in nutrient solutions, undergo transitions to coordinated activity with increasing cell density. The collective behavior is believed to arise through communication by chemical signaling via the extracellular solution. We studied large, heterogeneous populations of discrete chemical oscillators (similar to 100,000) with well- defined kinetics to characterize two different types of density- dependent transitions to synchronized oscillatory behavior. For different chemical exchange rates between the oscillators and the surrounding solution, increasing oscillator density led to ( i) the gradual synchronization of oscillatory activity, or ( ii) the sudden switching on of synchronized oscillatory activity. We analyze the roles of oscillator density and exchange rate of signaling species in these transitions with a mathematical model of the interacting chemical oscillators.
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