期刊
SCIENCE
卷 324, 期 5925, 页码 354-359出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1167093
关键词
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资金
- Kinetics Foundation
- William M. Keck Foundation
- Snyder Foundation
- Albert Yu and Mary Bechmann Foundation
- Wallace Coulter Foundation
- California Institute for Regenerative Medicine
- McKnight Foundation
- Esther A. and Joseph Klingenstein Fund
- NSF
- National Institute of Mental Health
- National Institute on Drug Abuse
- NIH Pioneer Award
- SGF
- SIGF
- Bio-X
- NARSAD
- John Blume Foundation
- Davis Phinney Foundation
Deep brain stimulation (DBS) is a therapeutic option for intractable neurological and psychiatric disorders, including Parkinson's disease and major depression. Because of the heterogeneity of brain tissues where electrodes are placed, it has been challenging to elucidate the relevant target cell types or underlying mechanisms of DBS. We used optogenetics and solid-state optics to systematically drive or inhibit an array of distinct circuit elements in freely moving parkinsonian rodents and found that therapeutic effects within the subthalamic nucleus can be accounted for by direct selective stimulation of afferent axons projecting to this region. In addition to providing insight into DBS mechanisms, these results demonstrate an optical approach for dissection of disease circuitry and define the technological toolbox needed for systematic deconstruction of disease circuits by selectively controlling individual components.
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