期刊
SCIENCE
卷 325, 期 5937, 页码 201-204出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1173635
关键词
-
资金
- NIH [P01 AG-11915, P51 RR000167]
- Research Facilities Improvement Program [RR15459-01, RR020141-01]
- William S. Middleton Memorial Veterans Hospital
Caloric restriction (CR), without malnutrition, delays aging and extends life span in diverse species; however, its effect on resistance to illness and mortality in primates has not been clearly established. We report findings of a 20-year longitudinal adult-onset CR study in rhesus monkeys aimed at filling this critical gap in aging research. In a population of rhesus macaques maintained at the Wisconsin National Primate Research Center, moderate CR lowered the incidence of aging-related deaths. At the time point reported, 50% of control fed animals survived as compared with 80% of the CR animals. Furthermore, CR delayed the onset of age-associated pathologies. Specifically, CR reduced the incidence of diabetes, cancer, cardiovascular disease, and brain atrophy. These data demonstrate that CR slows aging in a primate species.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据