期刊
SCIENCE
卷 326, 期 5949, 页码 120-123出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1176758
关键词
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资金
- Ministry of Education, Culture, Sports, Science and Technology, Japan
- Global Centers of Excellence Program in Chemistry of Nagoya University
- Japan Society for the Promotion of Science for Scientific Research
- Kurata Memorial Hitachi Science and Technology Foundation
Research to develop structurally discrete, chiral supramolecular catalysts for asymmetric organic transformations has met with limited success. Here, we report that a chiral tetraaminophosphonium cation, two phenols, and a phenoxide anion appear to self-assemble into a catalytically active supramolecular architecture through intermolecular hydrogen bonding. The structure of the resulting molecular assembly was determined in the solid state by means of x-ray diffraction analysis. Furthermore, in solution the complex promotes a highly stereoselective conjugate addition of acyl anion equivalents to alpha,beta-unsaturated ester surrogates with a broad substrate scope. All structural components of the catalyst cooperatively participate in the stereocontrolling event.
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