期刊
SCIENCE
卷 321, 期 5887, 页码 421-422出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1154433
关键词
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资金
- Medical Research Council [MC_U105559847, G0001354B, G0001354] Funding Source: researchfish
- MRC [MC_U105559847] Funding Source: UKRI
Obsessive-compulsive disorder (OCD) is characterized by repetitive thoughts and behaviors associated with underlying dysregulation of frontostriatal circuitry. Central to neurobiological models of OCD is the orbitofrontal cortex, a neural region that facilitates behavioral flexibility after negative feedback (reversal learning). We identified abnormally reduced activation of several cortical regions, including the lateral orbitofrontal cortex, during reversal learning in OCD patients and their clinically unaffected close relatives, supporting the existence of an underlying previously undiscovered endophenotype for this disorder.
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