期刊
SCIENCE
卷 321, 期 5891, 页码 964-967出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1159505
关键词
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资金
- NIAID NIH HHS [R01 AI060761-03, 5R01AI060761, R01 AI060761] Funding Source: Medline
Plants and animals sense pathogen- associated molecular patterns ( PAMPs) and in turn differentially regulate a subset of microRNAs ( miRNAs). However, the extent to which the miRNA pathway contributes to innate immunity remains unknown. Here, we show that miRNA- deficient mutants of Arabidopsis partly restore growth of a type III secretion- defective mutant of Pseudomonas syringae. These mutants also sustained growth of nonpathogenic Pseudomonas fluorescens and Escherichia coli strains, implicating miRNAs as key components of plant basal defense. Accordingly, we have identified P. syringae effectors that suppress transcriptional activation of some PAMP- responsive miRNAs or miRNA biogenesis, stability, or activity. These results provide evidence that, like viruses, bacteria have evolved to suppress RNA silencing to cause disease.
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