期刊
SCIENCE
卷 321, 期 5885, 页码 126-129出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1156951
关键词
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资金
- NIGMS NIH HHS [R01 GM077544-01, R01 GM061276, R01 GM077544, R01 GM077544-02, R01 GM061276-06, R01 GM061276-07, R01 GM061276-08, GM77544, GM61726] Funding Source: Medline
- National Research Foundation of Korea [R15-2004-033-05001-0] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
A simple negative feedback loop of interacting genes or proteins has the potential to generate sustained oscillations. However, many biological oscillators also have a positive feedback loop, raising the question of what advantages the extra loop imparts. Through computational studies, we show that it is generally difficult to adjust a negative feedback oscillator's frequency without compromising its amplitude, whereas with positive- plus- negative feedback, one can achieve a widely tunable frequency and near- constant amplitude. This tunability makes the latter design suitable for biological rhythms like heartbeats and cell cycles that need to provide a constant output over a range of frequencies. Positive- plus- negative oscillators also appear to be more robust and easier to evolve, rationalizing why they are found in contexts where an adjustable frequency is unimportant.
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