期刊
SCIENCE
卷 320, 期 5872, 页码 65-68出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1147888
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资金
- NEI NIH HHS [R01 EY013010-11, EY13010, R01 EY013010] Funding Source: Medline
- NIGMS NIH HHS [GM18568, R37 GM018568, R01 GM018568-36, R01 GM018568] Funding Source: Medline
Fundamental to living cells is the capacity to differentiate into subtypes with specialized attributes. Understanding the way cells acquire their fates is a major challenge in developmental biology. How cells adopt a particular fate is usually thought of as being deterministic, and in the large majority of cases it is. That is, cells acquire their fate by virtue of their lineage or their proximity to an inductive signal from another cell. In some cases, however, and in organisms ranging from bacteria to humans, cells choose one or another pathway of differentiation stochastically, without apparent regard to environment or history. Stochasticity has important mechanistic requirements. We speculate on why stochasticity is advantageous- and even critical in some circumstances- to the individual, the colony, or the species.
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