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MicroRNAs make big impression in disease after disease

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SCIENCE
卷 319, 期 5871, 页码 1782-1784

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AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.319.5871.1782

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Lately, microRNAs are garnering attention on the biomedical front, startling researchers with ever-expanding roles in disease. Studies show that microRNAs may offer a window into the development of various ailments, including cancer, diabetes, and heart failure, and provide a chance to strike disease targets that until now were unreachable. When poorly regulated, the molecules appear to drive cancer and a host of other diseases, and this could make them useful in diagnosing disease very early. MicroRNAs made by viruses, meanwhile, may help pathogens gain a foothold in their host, which could suggest new targets for antiviral drugs. MicroRNA-based therapeutic strategies are currently being considered.

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