期刊
SCIENCE
卷 321, 期 5887, 页码 401-404出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1158159
关键词
-
资金
- Howard Hughes Medical Institute Funding Source: Medline
- NCI NIH HHS [R01 CA123071-02, CA123071, R01 CA123071] Funding Source: Medline
- NIGMS NIH HHS [GM061126, R01 GM078620, GM078620, R01 GM078620-02, R01 GM061126, R01 GM061126-08] Funding Source: Medline
The atypical cadherin Fat acts as a receptor for a signaling pathway that regulates growth, gene expression, and planar cell polarity. Genetic studies in Drosophila identified the four-jointed gene as a regulator of Fat signaling. We show that four-jointed encodes a protein kinase that phosphorylates serine or threonine residues within extracellular cadherin domains of Fat and its transmembrane ligand, Dachsous. Four-jointed functions in the Golgi and is the first molecularly defined kinase that phosphorylates protein domains destined to be extracellular. An acidic sequence motif (Asp-Asn-Glu) within Four-jointed was essential for its kinase activity in vitro and for its biological activity in vivo. Our results indicate that Four-jointed regulates Fat signaling by phosphorylating cadherin domains of Fat and Dachsous as they transit through the Golgi.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据