4.8 Article

Programming DNA tube circumferences

期刊

SCIENCE
卷 321, 期 5890, 页码 824-826

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AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1157312

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资金

  1. National Research Foundation of Korea [2008-05279] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
  2. Direct For Computer & Info Scie & Enginr
  3. Division of Computing and Communication Foundations [0829797] Funding Source: National Science Foundation
  4. Division of Computing and Communication Foundations
  5. Direct For Computer & Info Scie & Enginr [0829798] Funding Source: National Science Foundation

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Synthesizing molecular tubes with monodisperse, programmable circumferences is an important goal shared by nanotechnology, materials science, and supermolecular chemistry. We program molecular tube circumferences by specifying the complementarity relationships between modular domains in a 42-base single-stranded DNA motif. Single-step annealing results in the self-assembly of long tubes displaying monodisperse circumferences of 4, 5, 6, 7, 8, 10, or 20 DNA helices.

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