期刊
SCIENCE
卷 320, 期 5876, 页码 670-673出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1155821
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Golgins, long stringlike proteins, tether cisternae and transport vesicles at the Golgi apparatus. We examined the attachment of golgin GMAP-210 to lipid membranes. GMAP- 210 connected highly curved liposomes to flatter ones. This asymmetric tethering relied on motifs that sensed membrane curvature both in the N terminus of GMAP- 210 and in ArfGAP1, which controlled the interaction of the C terminus of GMAP- 210 with the small guanine nucleotide-binding protein Arf1. Because membrane curvature constantly changes during vesicular trafficking, this mode of tethering suggests a way to maintain the Golgi architecture without compromising membrane flow.
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