期刊
SCIENCE
卷 321, 期 5885, 页码 117-120出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1154822
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After fertilization, maternal proteins in oocytes are degraded and new proteins encoded by the zygotic genome are synthesized. We found that autophagy, a process for the degradation of cytoplasmic constituents in the lysosome, plays a critical role during this period. Autophagy was triggered by fertilization and up- regulated in early mouse embryos. Autophagy- defective oocytes derived from oocyte- specific Atg5 ( autophagy- related 5) knockout mice failed to develop beyond the four- and eight- cell stages if they were fertilized by Atg5- null sperm, but could develop if they were fertilized by wild- type sperm. Protein synthesis rates were reduced in the autophagy- null embryos. Thus, autophagic degradation within early embryos is essential for preimplantation development in mammals.
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