期刊
SCHIZOPHRENIA RESEARCH
卷 192, 期 -, 页码 255-261出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.schres.2017.06.016
关键词
Schizophrenia; Inflammation; Gene expression; Cytokine; Veterans
类别
This study aimed to test whether a dysregulation of gene expression may be the underlying cause of previously reported elevated levels of inflammatory cytokines in veterans with schizophrenia. We performed a gnome-wide expression analysis in peripheral blood mononuclear cells from veterans with schizophrenia and controls, and our results show that 167 genes and putative Sod were differently expressed between groups. These genes were enriched primarily for pathways related to inflammatory mechanisms and formed networks related to cell death and survival, immune cell trafficking, among others, which is in line with previous reports and further validates the inflammatory hypothesis of schizophrenia. (C) 2017 Elsevier B.V. All rights reserved.
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