期刊
SCHIZOPHRENIA RESEARCH
卷 192, 期 -, 页码 9-15出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.schres.2017.04.005
关键词
Meta-analysis; Grey matter; Persistent negative symptoms; Schizophrenia
类别
资金
- National Natural Science Fund China [81571317]
- Beijing Training Project for the Leading Talents in S T [Z151100000315020]
- Beijing Municipal Science & Technology Commission Grant [Z161100000216138]
- Strategic Priority Research Program (B) of the Chinese Academy of Sciences [XDB02030002]
- CAS Key Laboratory of Mental Health, Institute of Psychology
- CAS-SAFEA International Partnership Program for Creative Research Teams [Y2CX131003]
Objectives: In the present study, we used Activation Likelihood Estimation (ALE) meta-analysis to quantitatively examine brain grey matter reduction in schizophrenia patients with persistent negative symptoms (PNS). Method: A total of 12 voxel-based morphometry (VBM) studies were included in ALE meta-analysis using more stringent criterion of PNS. Results: Significant grey matter reduction in the PNS group relative to controls was observed in the left caudate nucleus, the left precentral region, the left middle frontal region, the bilateral parahippocampal region, the left anterior cingulate region, the bilateral medial frontal gyrus, the thalamus and the insula. Conclusion: Our results suggest that brain regions in the reward network may be specifically related to PNS, especially the left caudate nucleus. It is possible that abnormality in reward processing may constitute the neural basis of PNS. (c) 2017 Elsevier B.V. All rights reserved.
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