期刊
SCHIZOPHRENIA RESEARCH
卷 202, 期 -, 页码 173-179出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.schres.2018.07.003
关键词
Sex differences; Resting state; Schizophrenia; Oxytocin; Vasopressin; Functional MRI
类别
资金
- 2012 NARSAD Young Investigator Grant from the Brain and Behavior Research Foundation
- National Institute of Health [K12HD055892, K08MH083888, MH083126, MH077851, MH078113, MH077945, MH077852, MH077862]
- National Natural Science Foundation of China [81371527]
- Program for Changjiang Scholars and Innovative Research Team in Universities of China
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [K12HD055892] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH078113, R01MH077852, R01MH077862, K08MH083888, R01MH077945, K23MH083126, R01MH077851, R01MH103366] Funding Source: NIH RePORTER
Background: Oxytocin (OT) and arginine vasopressin (AVP) exert sexually dimorphic effects on cognition and emotion processing. Abnormalities in these hormones are observed in schizophrenia and may contribute to multiple established sex differences associated with the disorder. Here we examined sex-dependent hormone associations with resting brain activity and their clinical associations in schizophrenia patients. Methods: OT and AVP serum concentrations were assayed in 35 individuals with schizophrenia (23 men) and 60 controls (24 men) from the Chicago BSNIP study site. Regional cerebral function was assessed with resting state fMRI by measuring the amplitude of low-frequency fluctuations (ALFF) which are believed to reflect intrinsic spontaneous neuronal activity. Results: In female patients, lower OT levels were associated with lower ALFF in frontal and cerebellar cortices (p's <0.05) and in female controls AVP levels were inversely associated with ALFF in the frontal cortex (p = 0.01). In male patients, lower OT levels were associated with lower ALFF in the posterior cingulate and lower AVP levels were associated with lower ALIT in frontal cortex (p's < 0.05). In male controls, lower OT levels were associated with lower ALFF in frontal cortex and higher ALFF in the thalamus (p's < 0.05). There were some inverse ALFF-behavior associations in patients. Conclusions: Alterations in peripheral hormone levels are associated with resting brain physiology in a sex-dependent manner in schizophrenia. These effects may contribute to sex differences in psychiatric symptom severity and course of illness in schizophrenia. (C) 2018 Elsevier B.V. All rights reserved.
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