期刊
SCHIZOPHRENIA RESEARCH
卷 152, 期 1, 页码 139-145出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.schres.2013.09.021
关键词
Atopic disorders; Asthma; Eczema; Childhood; Adolescence; Psychotic experiences; Psychotic symptoms; Schizophrenia; Inflammatory markers; IL-6; CRP; Cytokine; Immunity; Birth cohort; Prospective study; ALSPAC
类别
资金
- Wellcome Trust [094790/Z/10/Z, 095844/Z/11/Z, 088869/Z/09/Z, 092731]
- National Assembly for Wales
- NIHR [RP-PG-0606-1335]
- UK Medical Research Council [74882]
- University of Bristol
- Medical Research Council [G0001354B, MR/L010305/1, G1000183B, G0701503, G0801418, MC_PC_15018, G0001354] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0509-10215] Funding Source: researchfish
- MRC [G0801418, G0701503] Funding Source: UKRI
Objective: Schizophrenia is associated with atopy and increased inflammatory markers. We report a population-based longitudinal study of the associations between childhood atopic disorders, subsequent serum inflammatory markers, interleukin 6 (IL-6) and C-reactive protein (CRP), and the risk of psychotic experiences (PEs). Method: PEs were assessed at age 13 years (n = 6785). Presence of clinician-diagnosed atopic disorders (asthma and eczema) was determined from parent-completed questionnaires at age 10 years (n = 7814). Serum IL-6 and CRP were measured at age 9 years (n = 5076). Logistic regression examined the association between (1) atopy and PEs, (2) inflammatory markers and PEs, and (3) mediating effects of inflammatory markers on the atopy-PEs association. Linear regression examined the association between atopy and inflammatory markers. Age, gender, social class, ethnicity and body mass index were included as potential confounders. Results: At age 10 years, about 14% of the sample was reported to have asthma, 12% eczema, and 7% both asthma and eczema. Compared with children with no atopy, risk of PEs at age 13 years was increased for all of these groups; adjusted odds ratios (95% CI) were, respectively, 1.39 (1.10-1.77), 1.33 (1.04-1.69), and 1.44 (1.06-1.94). Atopy was associated with increased serum IL-6 and CRP; however, this did not mediate association between atopy and PEs. Inflammatory markers were not associated with later PEs. Conclusion: Childhood atopic disorders increase the risk of psychotic experiences in adolescence. Follow-up of these individuals will be useful to determine the effect of atopy and inflammation on different trajectories of early-life PEs. (C) 2013 The Authors. Published by Elsevier B.V. All rights reserved.
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