期刊
SCHIZOPHRENIA RESEARCH
卷 159, 期 2-3, 页码 543-545出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.schres.2014.08.031
关键词
Schizophrenia; Vitamin D; Hypovitaminosis D; Telomere length; Aggression; Negative symptoms
类别
资金
- NYU CTSA, National Center for Advancing Translational Sciences (NCATS), NIH [UL1TR000038]
- [RC1MH088843-02]
Vitamin D plays crucial roles in neuroprotection and neurodevelopment, and low levels are commonly associated with schizophrenia. We considered if the association was spurious or causal by examining the association of Vitamin D with Leukocyte Telomere Length (LTL), a marker of cellular aging. Vitamin D levels in 22 well characterized schizophrenia cases were examined with respect to symptoms, cognition, and functioning. LTL was assessed using quantitative polymerase chain reaction (qPCR). The results showed that 91% (20) had deficient or insufficient Vitamin D levels, which were associated with excitement and grandiosity, social anhedonia, and poverty of speech. Sex-specific analyses showed strong associations of hypovitamintosis D to negative symptoms and decreased premorbid adjustment in males, and to lesser hallucinations and emotional withdrawal, but increased anti-social aggression in females. In females LTL was furthermore associated with Vitamin D levels. This study demonstrates a relationship of low vitamin D levels with increased cellular aging in females. It is also the first study to demonstrate potential sex-specific profiles among schizophrenia cases with hypovitaminosis. (C) 2014 Elsevier B.V. All rights reserved.
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