期刊
SCHIZOPHRENIA RESEARCH
卷 149, 期 1-3, 页码 116-120出版社
ELSEVIER
DOI: 10.1016/j.schres.2013.06.043
关键词
Telomere length; Schizophrenia; Severity; Subphenotype; DNA extraction method; Case-control design
类别
资金
- National Genome Research Network (NGFN-plus) of the German Federal Ministry of Education and Research (BMBF) [01GS08144, 01GS08147]
- 7th Framework Programme of the European Union [HEALTH-F4-2009-242257]
- Olympia-Morata-Programme of the University of Heidelberg
- Academy of Finland
Previous studies have reported an association between shorter leukocyte telomere length and schizophrenia (SCZ). The aim of the present study was to replicate this finding in a large sample of SCZ patients (n = 539) and population-based controls (n = 519). In addition, the possible influence of SCZ severity on telomere length - as measured by age of onset, mode of onset, and course of the disorder - was investigated. Telomere length was negatively associated with age in both patients and controls. This is a consistently reported phenomenon, related to the problem of DNA end-replication. However, in contrast to previous findings, SCZ patients displayed longer telomeres compared to controls (p = 0.015). No association was found with any SCZ-severity subphenotype. Interestingly, recent studies have reported associations between longer leukocyte telomere length and both smaller hippocampal volume, and poorer episodic memory performance. Both phenotypes are common in patients with SCZ. Further studies are warranted to investigate whether the present association between SCZ and increased telomere length was driven by such associations, or rather by association with the clinical disease per se or other associated phenotypes, endophenotypes or lifestyle factors. (C) 2013 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据