期刊
SCHIZOPHRENIA RESEARCH
卷 134, 期 2-3, 页码 187-194出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.schres.2011.10.022
关键词
Schizophrenia; Hospitalisation; Antipsychotics; Cohort study; Long-acting injectable antipsychotics
类别
资金
- independent scientific board
- Janssen
- INSERM
- Astra-Zeneca
- GlaxoSmithKline
- Janssen (Johnson Johnson)
- Eli Lilly
- MSD
- Novartis
- Pfizer
- Roche
- Sanofi-Aventis
- LA-SER
- Laboratoires Servier
- Bristol Myers-Squibb
- Eutherapie
- Lilly
- Lundbeck
- Sanofi
- Servier
- Yolarx Consultants
Objective: The primary aim of this study was to compare the impact of risperidone long-acting injectable (R-LAI) to other antipsychotics on rates of hospitalisation in real-life settings. Method: The Cohort for the General study of Schizophrenia (CGS) followed 1859 patients diagnosed with schizophrenia (DSM-IV) from 177 psychiatric wards of public and private hospitals across France over a mean period of 12 months. These patients were ambulatory or had been hospitalised for less than 93 days at study entry. Recruitment was stratified for long-acting second-generation antipsychotic use. A multivariate Poisson regression adjusted for confounding with propensity scores and allowing for autocorrelation was used for the calculation of relative rates of hospitalisation with 95% confidence intervals. Results: The mean age of participants was 37.65 years, 68.3% were male and 36.7% were hospitalised for less than 93 days at study entry. Altogether, participants accumulated 796 hospital stays (53.4 per 100 person-years). R-LAI patients were slightly younger and had been hospitalised more often in the past 12 months compared to non-R-LAI users. The adjusted Poisson regression analysis showed R-LAI use to be associated with a lower rate of future hospitalisation: 0.66 [0.46-0.96] compared to non-R-LAI use, and 0.53 [0.32-0.88] compared to use of other LAIs. Conclusion: Use of R-LAI was associated with lower rates of hospitalisation compared to non-use of R-LAI. (C) 2011 Published by Elsevier B.V.
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