期刊
SCHIZOPHRENIA RESEARCH
卷 142, 期 1-3, 页码 83-87出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.schres.2012.09.014
关键词
D-serine; Schizophrenia; NMDA receptor; Negative symptoms; Aging
类别
资金
- Fundacao de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ, Brazil)
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq, Brazil)
- Long-Term Fellowship from the Human Frontier Science Program
- DECIT/SCTIE/MS
- SESDC
Changes in D-serine availability in the brain may contribute to the hypofunction of NMDA-glutamate receptors in schizophrenia; however, measurements of blood levels of D-serine in individuals with schizophrenia have not been consistent amongst previous studies. Here we studied plasma levels of D-serine and L-serine in 84 Brazilian individuals with schizophrenia and 75 gender-and age-matched controls. Plasma levels of D-serine and the ratio of plasma D-serine to total serine were significantly lower in individuals with schizophrenia as compared to the control group. Levels of D-serine were significantly and negatively correlated to the severity of negative symptoms of schizophrenia. We also observed that plasma levels of D-serine significantly decreased with aging in healthy controls. Our results suggest that the possible role of D-serine in the pathophysiology of schizophrenia should be further investigated, with possible implications for the drug treatment of this disorder. (C) 2012 Elsevier B.V. All rights reserved.
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