期刊
SCHIZOPHRENIA RESEARCH
卷 137, 期 1-3, 页码 169-173出版社
ELSEVIER
DOI: 10.1016/j.schres.2012.01.038
关键词
Insula; Signed differential mapping; Morphometry; Schizophrenia; Hallucinations
类别
资金
- Division of Psychiatry - School of Community Health Sciences of the University of Nottingham
Background: Despite being one of the most common symptoms of schizophrenia, determining the neural correlates of auditory hallucinations still remains elusive with various studies providing inconsistent results. Methods: We conducted a voxel-based meta-analysis of studies investigating the structural correlates of auditory hallucinations in schizophrenia. Results: 7 datasets including 350 patients were identified. There was a significant negative correlation between the severity of hallucinations and gray matter volume in the left insula and right superior temporal gyrus. Conclusion: With its key role in stimulus evaluation and optimizing prediction (proximal salience), the insula is likely to be a cardinal region along with superior temporal gyrus in the mechanism of auditory hallucinations in schizophrenia. (C) 2012 Elsevier B.V. All rights reserved.
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