4.6 Article

Porous PLGA microparticles to encapsulate doxorubicin and polyethylenimine/miR-34a for inhibiting the proliferation and migration of lung cancer

期刊

RSC ADVANCES
卷 5, 期 99, 页码 81445-81448

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ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ra15516a

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资金

  1. Natural Science Foundation of China [21204025, 81473142, 81373344]
  2. Ministry of Science and Technology of China (International Cooperation and Communication Program) [2011DFR51090]
  3. Science & Technology Department of Jilin Province [20130522005JH, 20140101140JC]
  4. Fundamental Research Funds for the Central Universities [JCKY-QKJC30]

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Porous PLGA microparticles were successfully prepared for achieving the co-delivery of doxorubicin and PEI25K/miR-34a, using ammonium bicarbonate as a porogen. The synergistic effect between these two components ensured the efficient anti-proliferative and anti-migration effects of porous PLGA microparticles on tumor cells.

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