期刊
SCHIZOPHRENIA RESEARCH
卷 132, 期 1, 页码 50-53出版社
ELSEVIER
DOI: 10.1016/j.schres.2011.07.027
关键词
Schizophrenia; Oxytocin; Psychosis; Social cognition; Theory of Mind; Social perception
类别
资金
- Foundation of Hope (FOH) for Research and Treatment of Mental Illness
- National Center for Research Services [UL1RR025747]
- GSK
- Novartis
Oxytocin has numerous prosocial and antipsychotic-like effects in animals. Prosocial effects of acute intranasal oxytocin administration have also been reported in human subjects. We conducted a randomized, placebo-controlled trial testing the effects of twice daily intranasal oxytocin treatment for 14 days on psychotic symptoms and social cognition in patients with schizophrenia. PANSS scores declined significantly and several social cognition measures improved significantly or nearly significantly in oxytocin (N = 11) but not placebo (N = 9) recipients. Our results suggest that, in addition to reducing classic psychotic symptoms, oxytocin may diminish certain social cognition deficits that are not improved by current antipsychotic medications. (C) 2011 Elsevier B.V. All rights reserved.
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