期刊
SCHIZOPHRENIA RESEARCH
卷 129, 期 2-3, 页码 149-155出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.schres.2011.03.014
关键词
Diffusion tensor imaging; Splenium; Genu; Corpus callosum; Meta-analysis
类别
资金
- NARSAD
- NIMH [MH076995]
- Advanced Center for Intervention and Services Research [MH074543]
- Mental Health Center for Intervention Development and Applied Research [MH080173]
- NSLIJ Research Institute General Clinical Research Center [M01 RR018535]
Background: The corpus callosum has been hypothesized to play an important role in neurobiological models of schizophrenia. Diffusion tensor imaging studies have provided evidence for a disruption in corpus callosum morphology in schizophrenia, but the regional distribution of abnormalities is not well known. Methods: We conducted 2 meta-analyses investigating the genu and splenium of the corpus callosum in schizophrenia, respectively, based on published diffusion tensor imaging studies that employed a region-of-interest approach. Seven studies investigating the genu and splenium involving a total of 202 patients with schizophrenia and 213 healthy volunteers were included. Results: The meta-analysis of the genu yielded an effect size of 0.223 and was not statistically significant. The second meta-analysis investigating the splenium yielded a modest effect size of 0.527 (p = 0.001), indicating that patients had lower fractional anisotropy in this region compared to healthy volunteers. Studies that included fewer men had a larger effect size for the splenium. Discussion: These findings implicate an abnormality involving the splenium of the corpus callosum in the neurobiology of schizophrenia as inferred by diffusion tensor imaging. A defect in the splenium could contribute to abnormalities in posterior interhemispheric connectivity in patients, including regions of the heteromodal association cortex. (C) 2011 Elsevier B.V. All rights reserved.
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