期刊
SCHIZOPHRENIA RESEARCH
卷 130, 期 1-3, 页码 78-85出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.schres.2011.04.016
关键词
Schizophrenia; Diffusion tensor imaging; Anterior commissure; White matter tractography; Fractional anisotropy; Trace
类别
资金
- National Institute of Health [K05 MH070047, R01 MH 50740, R01 MN 40799, P50MH 080272]
- Department of Veterans Affairs
- VA Schizophrenia Center
- National Alliance for Medical Image Computing (NA-MIC)
- National Institutes of Health Roadmap for Medical Research [U54 E8005149]
- National Health and Medical Council of Australia through University of Melbourne [NHMRC 520627]
Introduction: Alterations in white matter connections in schizophrenia have been investigated using diffusion tensor imaging (DTI). There is also evidence from post-mortem studies as well as from magnetic resonance imaging morphometry studies that the anterior commissure (AC) might be implicated in schizophrenia, but no studies, to date, have investigated the AC using DTI or tractography. Method: DTI scans were analyzed from 25 patients and 23 controls. Mean fractional anisotropy (FA) and trace were measured from the AC tracts. SANS and SAPS were used to evaluate clinical symptoms, and the Iowa Gambling Task, related to decision making, was also examined. Results: Results revealed a significant decrease in mean FA and a significant increase in mean trace of AC tracts in patients compared with controls. In addition, patients, but not controls, showed a negative correlation between age and AC integrity. Statistically significant positive correlations were also found between AC FA and total positive symptom score. Decision making was negatively correlated with FA in patients on the Iowa Gambling Task, but not in controls. Conclusion: This study provides quantitative evidence for a reduction of interhemispheric connectivity in schizophrenia within the AC. Negative correlation between age and AC FA in the patients is consistent with the idea that schizophrenia may be a disorder of white matter maturation. Positive correlation between FA and positive symptom is discussed in the context of white matter's established role in modulating neural conduction velocity. Published by Elsevier B.V.
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