期刊
SCHIZOPHRENIA RESEARCH
卷 128, 期 1-3, 页码 30-36出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.schres.2011.01.009
关键词
Docosahexaenoic acid; Arachidonic acid; Schizophrenia; Prenatal
类别
资金
- National Alliance for Research on Schizophrenia and Depression [NICHD N01-HD-1-3334, NICHD NO1-HD-6-3258, NHLBI RO1 - HL-40404]
- Robert Wood Johnson Foundation
- [NIMH 1K02MH65422]
It is believed that during mid-to-late gestation, docosahexaenoic acid (DHA), an n-3 fatty acid, plays an important role in fetal and infant brain development, including neurocognitive and neuromotor functions. Deficits in several such functions have been associated with schizophrenia. Though sufficient levels of DHA appear to be important in neurodevelopment, elevated maternal DHA levels have also been associated with abnormal reproductive outcomes in both animal models and humans. Our objective was to assess whether a disturbance in maternal DHA levels, measured prospectively during pregnancy, was associated with risk of schizophrenia and other schizophrenia spectrum disorders (SSD) in adult offspring. In order to test the hypothesis that abnormal levels of DHA are associated with SSD, a case-control study nested within a large, population-based birth cohort, born from 1959 through 1967 and followed up for SSD from 1981 through 1997, was utilized. Maternal levels of both DHA and arachidonic acid (AA), an n-6 fatty acid, were analyzed in archived maternal sera from 57 cases of SSD and 95 matched controls. There was a greater than twofold increased risk of SSD among subjects exposed to maternal serum DHA in the highest tertile (OR = 2.38, 95% CI = 1.19, 4.76, p = 0.01); no such relationship was found between AA and SSD. These findings suggest that elevated maternal DHA is associated with increased risk for the development of SSD in offspring. (C) 2011 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据