期刊
RSC ADVANCES
卷 5, 期 86, 页码 70101-70108出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ra13630j
关键词
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资金
- National Natural Science Foundation of China [20874090, 21074119]
In this work, aliphatic poly(urethane-amine) (PUA) grafted mesoporous hollow hydroxyapatite (H-HAP) microparticles were prepared via in situ polymerization in supercritical CO2. Thermal-responsive PUA acted as the on-off gates inside the mesoporous H-HAP due to the stretch and shrinkage of the PUA polymer chains at different temperatures. The PUA-grafted hollow HAP (PUA-g-H-HAP) microparticles displayed high specific surface area (95 m(2) g(-1)) and drug loading efficiency (60%). The in vitro drug release studies indicated that PUA-g-H-HAP microparticles exhibited distinguishable pH-and thermaldependent drug release properties, and PUA on-off switches enabled the DOX release in a reversible way by simply adjusting the environmental temperature. Moreover, compared to the hollow HAP microparticles having a higher amount of released DOX over the initial 2 h (about 24.4% of total released drug over 24 h) at 37 degrees C and pH 7.4, PUA-g-H-HAP microparticles displayed a sustained release property with the value of only 10.7% deriving from the blockage of the stretched PUA chains inside the mesoporous H-HAP.
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