期刊
SCHIZOPHRENIA RESEARCH
卷 121, 期 1-3, 页码 139-145出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.schres.2010.04.020
关键词
Gating-in; Gating-out; Auditory evoked potentials; P50; N100; P200; MMN; P300; Schizophrenia
类别
资金
- National Institute of Mental Health [1 R01 MH58784]
- Department of Psychiatry and Behavioral Neurosciences at Wayne State University
- NIMH [RO1 MH63476-01A, RO1 DA019055]
- NIDA
- Department of Psychiatry and Behavioral Neurosciences of Wayne State University
The interrelationship between the ability to inhibit incoming redundant input (gating out) and the ability of the brain to respond when the stimulus changes (gating in), has not been extensively examined. We administered a battery of auditory evoked potential tests to a group of chronic, medicated schizophrenia patients (N= 12) and a group of healthy subjects (N= 12) in order to examine relationships between gating out measures (suppression with repetition of the P50, N100, and P200 evoked responses), and the mismatch negativity (MMN) and the P300 event related potentials as measures of gating in. Gating ratios for N100 and P200 in a visual attention paired-click task differed significantly between groups. Mismatch negativity and P300 potential amplitudes were also significantly reduced in the patient group. When including all subjects (N= 24) a negative correlation was found between the P50 gating and the amplitude of the MMN. In healthy subjects this correlation was significantly stronger compared to schizophrenia patients. While no significant correlation was noted between the amplitudes of the P300 and any gating measures when all 24 subjects were included, a significant negative correlation was seen between the P200 gating and the P300 amplitudes in schizophrenia patients; an opposite trend was noted in healthy subjects. Finally, a positive correlation was seen between the P300 and MMN (to abstract deviance) amplitudes in healthy subjects, but the opposite was found in patients. These results suggest that further study of these interrelationships could inform the understanding of information processing abnormalities in schizophrenia. (C) 2010 Elsevier B.V. All rights reserved.
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