Increased temporal variability of auditory event-related potentials in schizophrenia and Schizotypal Personality Disorder

Previous studies suggest that deficits in neural synchronization and temporal integration are characteristic of schizophrenia These phenomena have been rarely studied in SPD which shares phenomenological and genetic similarities with schizophrenia Event-related potentials (ERPs) were obtained using an auditory oddball task from 21 patients with schizophrenia 19 subjects with SPD and 19 healthy control subjects Inter-trial coherence (ITC) and event-related spectral perturbation (ERSP) were measured across trials to target tones using time-frequency analysis ITC measures phase locking or consistency while ERSP measures changes in power relative to baseline activity P300 latency and amplitude were also measured from the averaged ERP to target tones In the time-frequency analysis subjects with SPD showed intact power but a deficit in the ITC in delta and theta frequencies compared to control subjects Patients with schizophrenia showed deficits for both ERSP and ITC in the delta and theta frequencies While patients with schizophrenia showed reduced P300 amplitude and delayed latency for averaged ERPs subjects with SPD did not differ from either group Synchronization or timing abnormalities may represent a biomarker for schizophrenia spectrum disorders and contribute to aberrant perceptual and cognitive integration (C) 2010 Elsevier BV All rights reserved