An efficient three-component synthesis of coumarin-3-carbamides by use of Ni-NiO nanoparticles as magnetically separable catalyst

An efficient and ecofriendly synthesis of coumarin-3-carbamides, a class of compounds known for their remarkable biological activities and fluorescent properties, has been developed by a three-component reaction of 2-hydroxybenzaldehydes, aliphatic primary/secondary amines and diethyl malonate using Ni-NiO nanoparticles as catalyst in the green solvent ethanol. The method is compatible with various functional groups and moieties.