期刊
SCHIZOPHRENIA RESEARCH
卷 117, 期 1, 页码 13-20出版社
ELSEVIER
DOI: 10.1016/j.schres.2009.09.030
关键词
Low-frequency oscillation; Schizophrenia; Resting state fMRI
类别
资金
- NIMH [RO1 MH064783, R21 MH084031, R37 MH049334, R01 MH066374]
- National Alliance for Research on Schizophrenia and Depression
Recently, a great deal of interest has arisen in resting state fMRI as a measure of tonic brain function in clinical populations. Most studies have focused on the examination of temporal correlation between resting state fMRI low-frequency oscillations (LFOs). Studies on the amplitudes of these low-frequency oscillations are rarely reported. Here, we used amplitude of low-frequency fluctuations (ALFF) and fractional ALFF (fALFF; the relative amplitude that resides in the low tuations (ALFF) and fractional ALFF (fALFF: the relative amplitude that resides in the low frequencies) to examine the amplitude of LFO in schizophrenia. Twenty-six healthy controls and 29 patients with schizophrenia or schizoaffective disorder participated. Our findings show that patients showed reduced low-frequency amplitude in proportion to the total frequency band investigated (i.e., fALFF) in the lingual gyrus, left cuneus, left insula/superior temporal gyros, and right caudate and increased fALFF in the medial prefrontal Cortex and the right parahippocampal gyrus. ALFF was reduced in patients in the lingual gyrus, cuneus, and precuneus and increased in the left parahippocampal gyrus. These results suggest LFO abnormalities in schizophrenia. The implication of these abnormalities for schizophrenic symptomatology is further discussed. (C) 2009 Elsevier B.V. All rights reserved.
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