期刊
SCHIZOPHRENIA RESEARCH
卷 122, 期 1-3, 页码 43-52出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.schres.2010.03.043
关键词
Schizophrenia; Dopamine; Molecular imaging; Positron emission tomography; Thalamus; Cortex
类别
资金
- Kettering Health Network Foundation
- Boonshoft Schizophrenia Center
- Anatomy and function of the thalamus in schizophrenia [MH60023]
- United States Air Force, Air Force Research Laboratory (AFRL/HEOP), Air Force Materiel Command [F33615-98-2-6002]
Background: Molecular imaging of dopaminergic parameters has contributed to the dopamine hypothesis of schizophrenia, expanding our understanding of pathophysiology, clinical phenomenology and treatment. Our aim in this study was to compare F-18-fallypride binding potential BPND in a group of patients with schizophrenia-spectrum illness vs. controls, with a particular focus on the cortex and thalamus. Methods: We acquired F-18-fallypride positron emission tomography images on 33 patients with schizophrenia spectrum disorder (28 with schizophrenia; 5 with schizoaffective disorder) and 18 normal controls. Twenty-four patients were absolutely neuroleptic naive and nine were previously medicated, although only four had a lifetime neuroleptic exposure of greater than two weeks. Parametric images of F-18-fallypride BPND were calculated to compare binding across subjects. Results: Decreased BPND was observed in the medial dorsal nucleus of the thalamus, prefrontal cortex, lateral temporal lobe and primary auditory cortex. These findings were most marked in subjects who had never previously received medication. Conclusions: The regions with decreased BPND tend to match brain regions previously reported to show alterations in metabolic activity and blood flow and areas associated with the symptoms of schizophrenia. (C) 2010 Elsevier B.V. All rights reserved.
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