期刊
SCHIZOPHRENIA RESEARCH
卷 123, 期 1, 页码 68-70出版社
ELSEVIER
DOI: 10.1016/j.schres.2010.08.002
关键词
Prodromal; Dyskinesia; Putamen; Caudate; Conversion; Psychosis
类别
资金
- National Institutes of Health [MH65079, MH14584-33, MH087258-01]
- NARSAD
- NIMH [P50 MH066286]
Although dyskinesias may be one of the first behavioral indicators of progressive striatal dysfunction, a mechanism critically implicated in the pathogenesis of psychotic disorders, little is known about the association between striatal structures and abnormal movements in high-risk populations. Thirty participants with a prodromal syndrome were rated for dyskinetic movements and underwent structural magnetic resonance imaging (MRI). Volumes of striatal brain structures were delineated. Elevated hyperkinetic movements were found to be associated with smaller putamen and results were replicated in the antipsychotic naive portion of the sample. Participants who converted over a 2-year follow-up period showed significantly smaller striatal volumes and a trend towards elevated dyskinetic movements, relative to those who did not convert. Movement abnormalities may reflect a striatal pathology that is present before formal psychosis onset, and potentially reflective of a heightened vulnerability for conversion. (C) 2010 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据