期刊
SCHIZOPHRENIA RESEARCH
卷 115, 期 2-3, 页码 317-324出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.schres.2009.07.019
关键词
Mecamylamine; Ad-lib smoking; Schizophrenia; Topography; Nicotine; Nicotinic acetylcholine receptor; Craving
类别
资金
- NCRR NIH HHS [UL1 RR024139-035870, UL1 RR024139] Funding Source: Medline
- NIAAA NIH HHS [T32 AA015496, T32 AA015496-05] Funding Source: Medline
- NIDA NIH HHS [K12 DA000167-18, K02 DA016611, K02 DA016611-03] Funding Source: Medline
Individuals with schizophrenia have higher plasma nicotine levels in comparison to non-psychiatric smokers, even when differences in smoking are equated. This difference may be related to how intensely cigarettes are smoked but this has not been well studied. Mecamylamine (MEC), a non-competitive nicotinic acetylcholine receptor (nAChR) antagonist, which has been shown to increase ad-lib smoking and to affect smoking topography, was used in the current study as a pharmacological probe to increase our understanding of smoking behavior, smoking topography, and resulting nicotine levels in smokers with schizophrenia. This preliminary study used a within-subject, placebo-controlled design in smokers with schizophrenia (n = 6) and healthy control smokers (n = 8) to examine the effects of MEC (10 mg/day) on ad-lib smoking behavior, topography, nicotine levels, and tobacco craving across two smoking deprivation conditions (no deprivation and 12-h deprivation). MEC, compared to placebo, increased the number of cigarettes smoked and plasma nicotine levels. MEC increased smoking intensity and resulted in greater plasma nicotine levels in smokers with schizophrenia compared to controls, although these results were not consistent across deprivation conditions. MEC also increased tobacco craving in smokers with schizophrenia but not in control smokers. Our results suggest that antagonism of high-affinity nAChRs in smokers with schizophrenia may prompt compensatory smoking, increasing the intensity of smoking and nicotine exposure without alleviating craving. Further work is needed to assess whether nicotine levels are directly mediated by how intensely the cigarettes are smoked, and to confirm whether this effect is more pronounced in smokers with schizophrenia. (C) 2009 Elsevier B.V. All rights reserved.
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