期刊
SCHIZOPHRENIA RESEARCH
卷 107, 期 2-3, 页码 249-254出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.schres.2008.09.030
关键词
SCH; Association; TAAR6; Gene; Case-control; Sample
类别
资金
- NIH [MH041953-13, MH068881-02]
To replicate previous association between TAAR6 and schizophrenia, including our own finding in the Irish Study of High Density Schizophrenia Families (ISHDSF) sample, we genotyped 12 single nucleotide polymorphisms (SNPs) in the Irish Case-Control Study of Schizophrenia (ICCSS) sample. Only rs9389020 provided nominal evidence for association (p<0.0228), which did not withstand the permutation testing (p<0.2196). The combined odds ratio from ISHDSF and ICCSS samples [OR (95%CI)= 1.0564 (1.0078-1.1074); p=0.02], while nominally significant, did not survive correction for multiple testing. Here we demonstrate that MARS is not associated with schizophrenia in the ICCSS sample. Published by Elsevier B.V.
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