期刊
SCHIZOPHRENIA RESEARCH
卷 99, 期 1-3, 页码 1-6出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.schres.2007.11.029
关键词
schizophrenia; cannabis; voxel based morphometry; magnetic resonance imaging; posterior cingulate
类别
资金
- NCATS NIH HHS [UL1 TR000005] Funding Source: Medline
- NCRR NIH HHS [M01 RR00056] Funding Source: Medline
- NIMH NIH HHS [K23 MH072995] Funding Source: Medline
Structural alterations of the brain in schizophrenia have been associated with genetic and environmental factors. Among the environmental factors, cannabis use has been associated with increased risk for patients with schizophrenia, but the effect of cannabis on their brain structure is unclear. We examined gray matter alterations in first episode schizophrenia patients (FES) with cannabis use (FES + C; n = 15) compared to FES without cannabis use (FES - C; n = 24) and 42 healthy controls who did not use cannabis. We conducted a voxel based morphometric analysis of a priori determined regions of interest consisting of the CB I receptor rich brain regions. We observed a decrease in gray matter density in the right posterior cingulate cortex (PCC) in FES + C when compared with FES-C. The results suggest that cannabis use may be associated with altered brain structure, in particular regions rich in CB I receptors. These findings need to be confirmed by larger, prospective studies. (C) 2007 Published by Elsevier B.V.
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