期刊
SCHIZOPHRENIA RESEARCH
卷 102, 期 1-3, 页码 150-162出版社
ELSEVIER
DOI: 10.1016/j.schres.2008.02.023
关键词
prodromal psychosis; imaging; voxel-based morphometry; schizophrenia
类别
Forty Untreated high-risk (HR) individuals for psychosis and 75 healthy control subjects (HC) matched for age, gender, handedness and educational level were investigated by structural MRI. HR subjects were recruited at the Early Detection and Intervention Centre for Mental Crises (FETZ) of the Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Germany. Measurements of gray matter volumes were performed by voxel-based morphometry using SPM5. The sample of HR subjects showed GM volume reductions in frontal, lateral temporal and medial temporal regions compared to the healthy control group. These regions are compatible with structural findings in the clinically apparent disease of schizophrenia. (c) 2008 Elsevier B.V All rights reserved.
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