期刊
SCHIZOPHRENIA RESEARCH
卷 102, 期 1-3, 页码 210-219出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.schres.2008.04.013
关键词
protocadherin; cadherin schizophrenia; bipolar disorder; chromatin
类别
资金
- NIMH NIH HHS [R01 MH073164, R01 MH073164-02, R01MH073164, R01 MH073164-03] Funding Source: Medline
Cadherins and protocadherins are cell adhesion proteins that play an important role in neuronal migration, differentiation and synaptogenesis, properties that make them targets to consider in schizophrenia (SZ) and bipolar disorder (BD) pathogenesis. Consequently, allelic variation occurring in protocadherin and cadherin encoding genes that map to regions of the genome targeted in SZ and BD linkage studies are particularly strong candidates to consider. One such set of candidate genes is the 5q31-linked PCDH family, which consists of more than 50 exons encoding three related, though distinct family members - alpha, beta, and gamma - which can generate thousands of different protocadherin proteins through alternative promoter usage and cis-alternative splicing. In this study, we focused on a SNP, rs31745, which is located in a putative PCDH alpha enhancer mapped by ChIP-chip, using antibodies to covalently modified histone H3. A striking increase in homozygotes for the minor allele at this locus was detected in patients with BD. Molecular analysis revealed that the SNP causes allele-specific changes in binding to a brain protein. The findings suggest that the 5q31-linked PCDH locus should be more thoroughly considered as a disease-susceptibility locus in psychiatric disorders. (c) 2008 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据